There are a few signs that may indicate that your Persian cat is experiencing health problems. Here are a few things to look out for:

1. Change in appetite or water intake: If your cat is eating less or drinking less water than usual, it could be a sign of a health problem.
2. Change in bathroom habits: If your cat is having trouble using the litter box, or if there are changes in the appearance or frequency of their urine or feces, it could be a sign of a health issue.
3. Change in energy level: If your cat is lethargic or inactive, it could be a sign of an underlying health issue.
4. Change in behavior: If your cat is displaying changes in behavior, such as increased aggression or decreased socialization, it could be a sign of a health problem.
5. Physical changes: If you notice any physical changes in your cat, such as weight loss, lumps or bumps, or changes in their coat or skin, it could be a sign of a health issue.

If you notice any of these changes in your Persian cat, it’s important to consult with a veterinarian as soon as possible. They will be able to diagnose and treat any underlying health issues.