Like any other natural or synthetic substance, the effectiveness of catnip can diminish over time or with repeated use. However, the degree of reduction in effectiveness can vary from one cat to another, depending on factors such as genetics, age, and overall health.

When a cat is exposed to catnip, it triggers a response in the brain that leads to the release of certain chemicals, including dopamine, which produces feelings of pleasure and satisfaction. Over time, the brain can become less sensitive to these chemicals, which can lead to a decrease in the cat’s response to catnip.

Furthermore, repeated exposure to catnip can desensitize a cat to its effects. Some cats may show a strong response to catnip the first time they encounter it, but with repeated use, the response can become less pronounced. This phenomenon is known as habituation.

To prevent habituation, it’s essential to use catnip in moderation and only offer it to cats a few times a week. Additionally, pet owners can try alternating different types of catnip or offering it in different forms, such as dried leaves, toys, or sprays, to keep their cats interested and responsive.

It’s also worth noting that not all cats will react to catnip in the same way, and some may not react at all. According to research, the response to catnip is genetically determined, with some cats having a gene that makes them highly responsive, while others have a gene that makes them less responsive or not responsive at all.

In conclusion, while catnip can be a useful tool in promoting relaxation and reducing anxiety in cats, its effectiveness can diminish over time or with repeated use. To prevent habituation, it’s essential to use catnip in moderation, offer it in different forms, and alternate its use with other forms of enrichment. If a cat does not respond to catnip, there are other natural and synthetic options available that may be more effective in promoting relaxation and reducing anxiety.